ESR10: Multimodal imaging of supramolecular logic gates in endothelial pathology models ex-vivo

at Jagiellonian University Krakow/Poland
Faculty of Chemistry and Jagiellonian Centre for Experimental Therapeutics
Prof. Dr. Malgorzata Baranska (baranska@chemia.uj.edu.pl)

Candidates with a background in chemistry, biochemistry and/or spectroscopy are invited to apply for a PhD position in the Raman Imaging Group (head: Prof. Malgorzata Baranska) in the Faculty of Chemistry at Jagiellonian University (JUK, Krakow, Poland).

The aim of the doctoral project is to determine response of supramolecular logic gates (labs-on-a-vesicle) in endothelial pathology models ex vivo in order to evaluate influence of tissue environment on labs-on-a-vesicle behaviour. The candidate will investigate tissue samples from animals in murine models of endothelial pathologies (for example atherosclerosis and/or hypertension) using multimodal (Raman/fluorescence) imaging to correlate Raman signals (information about chemical changes in the tissue) with luminescence signals from supramolecular logic gates. To get additional information about the activity of labs-on-a-vesicle in ex vivo models, response to light-triggered NO-release molecules will be evaluated. The comparison of the obtained results with data regarding in vitro models will enable to understand the influence of intermolecular interactions on spectral properties of labs-on-a-vesicle.

Secondments: study on different animal models (2 months at SAS/Slovakia), correlating Raman-spectroscopic and MS/GC-data of ex-vivo samples (one month at the company Interscience/Netherlands) and application of metabolomic methods to assess cytotoxicity of supramolecular logic sensors (2 months at UL/Netherlands)

Requirements: Master/Engineering degree in Chemistry or Biochemistry, preferably with majors in Spectroscopy. Interest in the field of spectroscopy, microscopy and chemometrics applied to biological samples is required. Knowledge in the field of (bio)chemical sensing and endothelial biochemistry are great assets. As an equal opportunity employer Jagiellonian University is committed to increase the percentage of female scientists and therefore especially encourages them to apply.

Planned start date: 1st June 2019

Application deadline: 28th February 2019

Contact: Applications should be sent to Prof. Malgorzata Baranska at baranska@chemia.uj.edu.pl. Please, insert “LogicLab PhD” as the e-mail title.