ESR8: Functionalization of living endothelial cells with TTA-upconversion logic gates and photo-NORMs

at Leiden University /The Netherlands
Leiden Institute of Chemistry
Dr. Sylvestre Bonnet (bonnet@chem.leidenuniv.nl)

Candidates with a background in synthesis, photochemistry, chemical biology, and/or bioinorganic chemistry, are invited to apply for a PhD position in the department of Metals in Catalysis, Biomimetics, and Inorganic Materials (MCBIM, sub-group Dr. Sylvestre Bonnet)  at Leiden Institute of Chemistry (Leiden University, The Netherlands).

The ESR will study the influence of hydrophobic substituents on the membrane/water partition coefficient, bi-dimensional diffusion coefficient, and cellular toxicity, of photoactive NO-releasing molecules (photoNORMs) and upconverting molecular logic gated sensors. The project involves synthesis and physical chemistry; its overall objective is to obtain molecular sensors and photoNORMs that can be integrated in liposomes formulation that can be used to functionalize living endothelial cells with the sensing or NO-release function.

Secondments: lifetime microscopy and dye diffusion studies (3 months at DCU/Ireland), upconversion NO release studies (2 months at FSU/Germany) and work on a microfluidic artery model (one month at the company Mimetas/Netherlands)

Requirements: Master/Engineering degree in Chemistry. Good knowledge and interest in both synthetic and physical-chemical work. Proven competence in the field of synthesis, spectroscopy, chemical biology, or bioinorganic chemistry, is required. Knowledge in the field of (bio)chemical sensing, membrane (bio)chemistry are great assets.
Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups.

Planned start date: 1st July 2019

Application deadline: 30th April 2019

Contact: Applications should be addressed to Dr. Sylvestre Bonnet and sent at snellenbergy@chem.leidenuniv.nl with the subject “application LOGICLAB”. Informal enquiries may be addressed to Dr. Sylvestre Bonnet at bonnet@chem.leidenuniv.nl