ESR2: Highly fluidic lipid bilayers as 2D cell membrane models

at Dublin City University/Ireland
School of Chemical Sciences
Prof. Dr. Tia Keyes (tia.keyes@dcu.ie)

Candidates with a background in chemistry, (bio)chemistry, biophysics or related disciplines are invited to apply for a PhD position in Supramolecular Biophysics group; (head: Prof. Tia Keyes) at the School of Chemical Sciences and National Centre for Sensor Research, Dublin City University, Ireland.

The aim of the doctoral project is to build robust fluidic lipid membrane models into which photoactive supramolecular assemblies are reconstituted. The candidate will build microfluidic lipid membrane models and assemble photoactive membrane associating constituents of molecular sensors into the substrates and will assess the performance of the sensors in the model. He/she will investigate the role of the tail group in optimising membrane re-constitution of supramolecular components and the photophysics of the assemblies using fluorescence lifetime imaging and fluorescence correlation spectroscopy of the molecular sensors and will elucidate the role of different lipid environments on the photophysics and sensor properties of the assemblies. The candidates experience will include nanofabrication, lipid membrane/liposome biophysics, and fluorescence microscopy.

Secondments: studying data from transient absorption microscopy (2 months at Leibniz-IPHT, Germany) to understand photophysical interactions that underlie sensor performance and to correlate data with FLIM studies, investigating supramolecular assemblies in liposomes (3 months at UL, Netherlands) and modelling membrane diffusion processes using computational methods (one month at the company SciClus, Germany).

Requirements: Masters degree in Chemistry, Biochemistry, Biophysics or related discipline. Good knowledge and interest in both experimental and theoretical work. Interest in the field of photochemistry, photophysics and Biophysics and/or nanofabrication is required. Knowledge in the field of electrochemistry, self-assembled monolayers, liposomes and/or Langmuir Blodgett method are great assets. As an equal opportunity employer Dublin City University is committed to increase the percentage of female scientists and therefore especially encourages them to apply.

Planned start date: 1st April 2019

Application deadline: 16th February 2019

Contact:

Applications should be sent to Ms. Sheila Boughton: sheila.boughton@dcu.ie

Informal enquiries may be addressed to Prof. Tia Keyes at tia.keyes@dcu.ie