Molecular logic gates as tailor-made diagnostic tools for early identification of endothelial dysfunction

A dysfunction of cells lining the inner walls of blood vessels, i.e. the endothelium, is the primary cause of many lifestyle related diseases such as atherosclerosis. According to the WHO, those diseases accounted for 60% of all deaths worldwide in 2005. Tailor-made diagnostic tools for early and reliable identification of endothelial dysfunction are urgently needed both in fundamental research and clinical routine, respectively.

Our Idea

LOGIC LAB provides a multi-disciplinary research network, in which 14 Early-Stage Researchers will closely work together to overcome current obstacles in intracellular diagnostics.

Our Objectives

In LOGIC LAB, we aim to develop a new concept of molecular logic sensors that will pave the way for their application in biological matrices. Thus, we want to bring intracellular molecular logic sensing out of its niche existence.

Our Approach

LOGIC LAB uniquely combines academic and industrial expertise in synthesis and optical spectroscopy, molecular modelling, organ-on-a-chip microfluidic systems, metabolic profiling, endothelium-related diseases and toxicology.

Key Facts
Overall Funding

Beneficiaries and Partners

The LogicLab consortium combines expertise of 9 beneficiaries and 6 associated partners researching in the fields of synthetic, supramolecular and theoretical chemistry, spectroscopy as well as cell biology and microfluidics.